Lifitegrast is an integrin antagonist. It binds to LFA-1 (leukocyte function antigen 1), which occurs mainly on T cells and white blood cells. This results in fewer bonds to the inflammatory mediating ICAM-1 (intercellular adhesion molecule). ICAM-1 is over-expressed in dry eyes (too strong). Lifitegrast is therefore used for the treatment of dry eyes.
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