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Intermediates for BioPharma

Within the Division of Intermediates for BioPharma, Midas is providing services and products in the field of intermediates and building blocks for biopharmaceuticals such as drug conjugates (Linkers & Payloads), Peptides (natural & unnatural Amino-acids) as well as Nucleic Acids (Nucleotides, Cap-analogues and Phosphoramidites).

Working with Midas means:

Full service, from enquiry to delivery, taking care of all customer needs.
Broad portfolio of building blocks, ready-to-use as well as customized contract manufacturing or other customized solutions.
Technical experienced PhD Chemists and Biochemists in the fields of peptide, RNA/DNA, oligonucleotide and drug conjugate synthesis..
Support in quality and regulatory related topics such as compilation of CMC documentation for filing in different territories, taking care of Deficiency letters or Life Cicle Management.
Midas is working only with qualified manufacturing partners with production at GMP compliant/certified sites from R&D to commercial scales, ensuring high quality products.
With affiliates in nine countries (including China, India and US) and manufacturing partner worldwide, Midas has access to all markets and can make use of this global sourcing and marketing network to find the matching intermediate or building block for biopharmaceuticals.

Our BioPharma-Portfolio

Find out more about our most important BioPharma fields!

Nucleic Acids
Midas is offering building blocks for the chemical or enzymatic synthesis of all classes of Nucleic Acid therapeutics (incl. mRNA as well as Oligonucleotides).

We offer:
- All necessary building blocks for RNA and DNA synthesis
- Customized manufacturing services for specific phosphoramidites and cap analogues available
- Existing portfolio of (modified) phosphoramidites, tri-, di- and monophosphate nucleotides and protected nucleosides
Drug conjugates
In the field of drug conjuagtes Midas is actively working with intermediates for Antibody-drug conjugates as well as other drug conjugates (e.g. peptide-drug conjugates, small molecule-drug conjugates, …)

Midas can provide:
- Fermentative as well as full chemically synthesized payloads
- Cleavable and non-cleavable linkers
- One-Stop-Shop for drug conjugates (From the synthesis of the building blocks up to the bioconjugation of the final conjugate)
Besides our ready-to-use products, please also ask us for our customized solutions and contract manufacturing of payloads or linkers.
Peptides
- Portfolio of natural and unnatural amino acids
- High chemical and optical purity > 99.9%

Find your Product

154110-40-4

5'-O-DMT-N4-acetyl-2'-deoxycytidine-CE phosphoramidite

146478-72-0

4(S)-Acetoxy-N-[(2R,3R,5S,6S)-6-[5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methyl-2(E),4(E)-pentadienyl]-2,5-dimethyltetrahydropyran-3-yl]-2(Z)-pentena

108212-76-6

N-Acetyl-calicheamicin

32909-05-0

N4-Acetyl-2'-deoxycytidine

159414-97-8

N4-Acetyl-2'-deoxy-2'-fluorocytidine

100898-63-3

5'-O-DMT-N4-acetyl-2'-deoxycytidine

199593-09-4

5'-O-DMT-2'-OMe-acetyl-cytidine-CE phosphoramidite

159414-99-0

5'-O-DMT-2'-F-acetyl-deoxycytidine-CE phosphoramidite

113886-71-8

N4-Acetyl-2'-O-methyl-cytidine

56-65-5

Adenosine-5'-triphosphoric acid

23214-92-8

Adriamycin

72902-38-6

Ansamitocin Derivative Tn-006

4803-27-4

Anthramycin

4546-72-9; 305808-19-9

N6-Benzoyl-2'-deoxyadenosine

4836-13-9

N4-Benzoyl-2'-deoxycytidine

104992-55-4

5'-O-DMT-2'-O-TBDMS-N6-benzoyl-adenosine-CE phosphoramidite

136834-22-5

5'-O-DMT-2'-F-Benzoyl-deoxyadenosine-CE phosphoramidite

110782-31-5

5'-O-DMT-2'-OMe-benzoyl-adenosine-CE phosphoramidite

340162-93-8

N4-Benzoyl-2’-O-(2-ethoxyethyl)-5-methylcytidine

105931-57-5

5'-O-DMT-N4-benzoyl-2'-deoxy-5-methylcytidine-CE phosphoramidite

251647-48-0

5'-O-DMT-N6-Benzoyl-2'-MOE-adenosine

251647-53-7

5'-O-DMT-2'-O-MOE-Benzoyl-adenosine-CE phosphoramidite

182496-01-1

5'-O-DMT-2’-MOE-N6-benzoyl-5-methycytidine

163759-94-2

5'-O-DMT-2’-O-MOE-Benzoyl-5-methylcytidine-CE phosphoramidite

333335-93-6

N6-Benzoyl-2'-MOE-adenosine

85079-00-1

N6-Benzoyl-2'-OMe-adenosine

102690-88-0

Bis-(2-cyanoethyl) N,N-diisopropylphosphoramidite

61093-23-0

Bis-3',5'-cyclic diguanylic acid

168332-12-5

(S)-DMT-Glycidolthymin

110764-72-2

5'-O-DMT-N6-Benzoyl-2'-OMe-adenosine

118362-03-1

5'-O-DMT-2'-O-TBDMS-uridine-CE phosphoramidite

150780-67-9

5'-O-DMT-2'-OMe-Ibu-guanosine-CE phosphoramidite

110764-79-9

5'-O-DMT-2'-OMe-Uridine-CE Phosphoramidite

560088-79-1

Boc-8-amino-3,6-dioxaoctanoic acid DCHA

440327-50-4

N2-iso-Butyroyl-2’-O-(2-methoxyethyl)guanosine

163586-86-5

N-Isobutyryl-2',3'-acetyl-guanosine

68892-42-2

N2-Isobutyryl-2'-deoxyguanosine

182625-68-9

Bz-G-(S)-GNA phosphoramidite

108212-75-5

Calicheamicin γ(1)

144089-97-4

5'-O-DMT-2'-F-Isobutyryl-deoxyguanosine-CE phosphoramidite

102691-36-1

2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphorodiamidite

65-46-3

Cytidine

65-47-4

Cytidine-5'-triphosphoric acid trisodium salt

796073-69-3

N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine

139504-50-0

N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine

101515-08-6

7-Deazadeoxyadenosine-5'-triphosphate lithium salt

958-09-8; 16373-93-6

2’-Deoxyadenosine

98796-53-3

Deoxyadenosine-CE phosphoramidite

2922-74-9

2'-Deoxyadenosine-5'-monophosphate disodium salt

1927-31-7

2'-Deoxyadenosine-5'-triphosphate sodium salt

951-77-9; 207121-53-7

2'-Deoxycytidine

102212-98-6

Deoxycytidine-CE phosphoramidite

13085-50-2

2'-Deoxycytidine-5'-monophosphoric acid disodium salt

102783-51-7

2'-Deoxycytidine-5'-triphosphoric acid disodium salt

951-78-0

2'-Deoxy-D-uridine

64183-27-3

2'-Deoxy-2'-fluoroadenosine

10212-20-1

2'-Deoxy-2'-fluorocytidine

78842-13-4

2'-Deoxy-2'-fluoroguanosine

784-71-4

2'-Deoxy-2'-fluorouridine

875302-39-9

Deoxyguanosin-CE-phosphoramidite

961-07-9; 312693-72-4

2'-Deoxyguanosine

33430-61-4

2'-Deoxyguanosine-5'-monophosphoric acid disodium salt

93919-41-6

2'-Deoxyguanosine-5'-triphosphoric acid trisodium salt

838-07-3

2'-Deoxy-5-methylcytidine

42155-08-8

2'-Deoxyuridine-5'-monophosphoric acid disodium salt

85326-06-3

2',3'-Dideoxyguanosine

81246-83-5

5'-O-DMT-N2-Isobutyryl-guanosine

143824-78-6

Fmoc-L-Trp(Boc)

1069067-08-8

1-(1,1-Dimethylethyl) 10-oxo-5,8,14,17-tetraoxa-2,11-diazanonadecanedioate

64272-68-0

1,3-Dimethylpseudouridine

1228105-51-8

Dm1-Smcc

168332-14-7

(R)-DMT-Glycidol thymine

93183-15-4

5'-O-DMT-N2-Isobutyryl-2'-deoxyguanosine-CE phosphoramidite

875302-47-9

5'-O-DMT-3'-O-TBDMS-N1-methylpseudouridine-CE phosphoramidite

144429-58-3

5'-O-DMT-3'-O-TBDMS-pseudouridine

133120-89-5

Dov-Val-Dil-OH TFA

400647-59-8

Doxorubicin-SMCC

1116745-06-2

Duocarmycin Dm (Free Base)

1599440-33-1

DXD

124412-57-3; 124759-75-7

Dynemicin

99674-26-7

Esperamicin A1

61135-33-9

5-Ethynyl-2'-deoxyuridine

171335-80-1

Exatecan

169869-90-3

Exatecan mesylate

79990-15-1

Fmoc-D-alanine

175453-08-4

Fmoc-4-Cl-Phenylalanine

138774-94-4

Fmoc-D-2-Naphthylalanine

175453-07-3

Fmoc-3-pyridyl alanine

146954-75-8

5'-O-DMT-2'-F-Deoxyuridine-CE phosphoramidite

852155-68-1

5'-Guanylic acid 7-methyl mono anhydride with 1H-imidazol-1-ylphosphonic acid disodium salt

163759-49-7

2’-MOE-5-Methyluridine

104579-02-4

N4-Benzoyl-2'-deoxy-5-methylcytidine

54-42-2

Idoxuridine

57103-68-1

Maytansinol

66584-72-3

Maytansinol isobutyrate

1870916-87-2

MC-Val-Ala-PAB

159857-80-4

MC-Val-Cit-PAB

MC-Val-Cit-PAB-MMAE

847649-65-4

5-Methoxyuridine 5'-triphosphate

1867-73-8; 60209-41-8

N6-Methyladenosine

117723-13-4

7-Methyl-guanosine-5'-diphosphate, TEA Salt

138148-62-6

N-Methyl-N-[(3-methyldithio)-1-oxopropyl]-L-alanine

796073-55-7

4-Methyl-4-(methyldithio)pentanoic acid

94889-79-9

7-Methyl-3'-O-methylguanosine-5'-monophosphate

2089461-52-7

7-Methyl-3'-O-methyl-guanosine 5'-(trihydrogen diphosphate) inner salt, compd. with N,N-Diethylethanamine

13860-38-3

1-Methylpseudouridine

1446012-27-6

1-Methylpseudouridine-5'-monophosphate

1428903-59-6

N1-Methylpseudouridine-5'-triphosphate sodium salt

474645-27-7

Monomethyl auristatin E

745017-94-1

Monomethyl auristatin F

1159174-80-7

N4-Ac-C-(S)-GNA phosphoramidite

851050-24-3

N6-Bz-A-(S)-GNA phosphoramidite

885322-06-5

N4-Bz-C-(S)-GNA phosphoramidite

875302-43-5

5'-O-DMT-3'-O-TBDMS-N1-Methypseudouridine

287737-43-3

2'-O,4'-C-Ethyleneadenosine

287737-34-2

2'-O,4'-C-Ethylenecytidine

287737-59-1

2'-O,4'-C-Ethyleneguanosine

287737-47-7

2'-O,4'-C-Ethyleneuridine

206055-70-1

2'-O,4'-C-Methylene adenosine

207131-16-6

1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)-guanine

206055-69-8

2’-O,4’-C-Methylenecytidine

200435-92-3

1-(2'-O,4-C-Methylene-β-D-ribofuranosyl)-uridine

121058-88-6

5'-O-DMT-2'-O-TBDMS-N4-Acetyl-cytidine-CE phosphoramidite

67219-55-0

5'-O-DMT-N4-Benzoyl-2'-deoxycytidine

104579-03-5

5'-O-DMT-N4-Benzoyl-2'-deoxy-5-methylcytidine

330628-04-1

5'-O-DMT-2'-Deoxyguanosine(DMF)-CE phosphoramidite

147201-04-5

5'-O-DMT-2'-O-TBDMS-N2-Isobutyryl-guanosine-CE phosphoramidite

40615-39-2

5'-O-DMT-Thymidine

98796-51-1

5'-O-DMT-Thymidine-CE phosphoramidite

251647-50-4

5'-O-DMT-2’-MOE-N2-Isobutyrylguanosine

251647-55-9

5'-O-DMT-2’-O-MOE-Isobutyryl-guanosine-CE phosphoramidite

163759-50-0

5'-O-DMT-2’-MOE-5-Methyluridine

163878-63-5

5'-O-DMT-2'-O-Methyl-5-methyluridine

875302-41-3

5'-O-DMT-2'-O-TBDMS-N1-Methylpseudouridine

875302-45-7

5'-O-DMT-2'-O-TBDMS-N1-Methylpseudouridine-CE phosphoramidite

144429-56-1

5'-O-DMT-2'-O-TBDMS-Pseudouridine

144429-55-0

5'-O-DMT-Pseudouridine

168427-74-5

2'-O-(2-Methoxyethyl)-adenosine

473278-54-5

2'-O-(2-Methoxyethyl)-guanosine

256224-03-0

3’-O-(2-Methoxyethyl)-guanosine

244105-55-3

2'-O-(2-Methoxyethyl)-5-methylcytidine

62828-60-8

2′-O-Methyl-5′-O-phosphonoadenylyl-(3′➝‬5′)-guanosine

2140-79-6

2'-O-Methyladenosine

10300-22-8

3'-O-Methyladenosine

2140-72-9

2'-O-Methylcytidine

20594-00-7

3'-O-Methylcytidine

2140-71-8

2'-O-Methylguanosine

10300-27-3

3'-O-Methylguanosine

78771-34-3

3'-O-Methylguanosine-5'-trihydrogen diphosphate

400806-41-9

3'-O-Methyl-5'-guanylic acid

2305415-87-4

3'-O-Methyl-5-methyluridine

2140-76-3

2'-O-Methyluridine

6038-59-1

3'-O-Methyluridine

65360-02-3

N,2'-O,3'-O-Triacetylguanosine

10017-66-0

alpha-Pseudouridine

1445-07-4

beta-Pseudouridine

1157-60-4

Pseudouridine 5'-monophosphate

1175-34-4

Pseudouridine-5'-triphosphate

12684-33-2

Sibiromycin

391611-36-2

Spliceostatin A

3930-19-6

Streptonigrin

55750-63-5

N-Succinimidyl-6-maleimidohexanoate

64987-85-5

SMCC

1193111-37-3

Sulfo-SNPB

1193111-39-5

Sulfo-SPDB

86-01-1

5'-(Tetrahydrogentriphosphate)-guanosine

168332-13-6

(S)-T-GNA phosphoramidite

1426953-21-0

Thailanstatin A

20235-78-3

2-Thiouridine

50-89-5; 157049-40-6

Thymidine

33430-62-5

Thymidine-5'-monophosphoric acid disodium salt

18423-43-3

Thymidine-5'-triphosphoric acid sodium salt

494784-15-5

U-(S)-GNA phosphoramidite

58-96-8

Uridine

19817-92-6

Uridine-5'-triphosphoric acid trisodium salt

644981-35-1

Val-Cit-PAB-MMAE

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Your Contact

Dr. Danielle Leone-Stumpf

Dr. Danielle Leone-Stumpf

International Division
Senior Director Intermediates for Pharma & BioPharma

Midas Pharma GmbH
Rheinstr. 49
55218 Ingelheim
Germany

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