Irinotecan hydrochloride

Irinotecan hydrochloride


100286-90-6, 136572-09-3




Irinotecan hydrochloride is a semi-synthetic derivative of camptothecin, an alkaloid of Camptotheca acuminata. It is a prodrug that is converted into a potent metabolite (SN-38). Irinotecan inhibits DNA topoisomerase I, which is often overactive in tumors. Non-growing cells are therefore not affected. It is used to treat metastatic colon carcinomas (in combination with 5-FU and folinic acid) and experimentally it is used against other tumors.



C33H44N4O9 • HCl • H2O

Molecular weight

677.19 g/mol

Molecular size


Controlled Substance





Antineoplastic drugs

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Marius Hang

Marius Hang

International Division
Director API Export

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