In the recent years, generic drug shortages have been raised increasing attention in the EU. The reasons for these drug shortages are manifold. They could be caused by quality issues at a key supplier, unexpected increase of demand for a certain product, price pressure leading to strategy changes/ outsourcing activities or incidents causing production stops in the chemical supply chain.
Although there might be a large number of manufacturers for a certain API, these are often directly or indirectly dependent on just a few raw material / starting material suppliers. In case of an incident at the raw material supplier, it might have an impact on the API availability in the whole market.